ダイアライザーの種類は何ですか?
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2021-12-01
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LEPU
透析器は、透析膜と腎臓に代わるその支持構造で構成されています。 透析膜は、透析液から血液を分離する透析器の主要部分である。 透析中、血液と透析液は膜の両側で反対方向に流れ、水と溶質は半透膜を介して交換されます。 透析器の性能は、透析治療の効果を決定し、血液透析プログラムの開発のための重要な参照因子である。
The characteristics of the HemoDialyzer are composed of two parts: design characteristics and working characteristics. Design features include the configuration of the Dialyzer, the pre-charge of the blood chamber and the dialysate chamber, the type of membrane, and the biocompatibility. Working characteristics include the transfer rate of different solutes and water. There are several classification methods for Dialyzers.
」となります。 Dialyzerの构成による分类
Dialyzers are divided into tube type, flat type, and hollow fiber type. At present, the commonly used Dialyzers are hollow fiber type, and the flat-type and tube-type Dialyzers used in the early days have been basically eliminated.
The 中空繊维Dialyzer is composed of 8000-12000 hollow fibers, the fiber inner diameter is 200-300um, and the wall thickness is 2-30um. The hollow fibers are bundled into bundles and placed in the formed Dialyzer casing, and the casing and the dialyzing membrane are sealed with polyurethane. The blood flows through the hollow fibers, and the dialysate flows in the opposite direction outside the fibers.
」とした。 Dialyzerの膜材料による分类
膜材料によると、透析器は4つのカテゴリーに分けることができます。
1. Regenerated cellulose membrane Dialyzer, including copper imitation membrane and copper ammonia membrane Dialyzer. There are free hydroxyl groups on the surface of cellulose, which can react with blood components and has poor biocompatibility. After the Cupra treatment, the fiber surface is smoother and the biocompatibility is improved.
2. Acetate cellulose membrane Dialyzer. The cellulose is acetylated before the film is formed, which improves the biocompatibility and performance of the film.
3. Replace the fiber membrane Dialyzer. Blood imitation membrane is an alternative copper imitation membrane because its surface-free hydroxyl groups are covered by tertiary ammonia compounds, which have good biocompatibility.
4. Synthetic fiber membrane Dialyzer. Materials for this Dialyzer include polyacrylonitrile, polymethylmethacrylate, polysulfone, polycarbonate, polyethylene, and polyamide. They have a higher transport coefficient and ultrafiltration coefficient, better biocompatibility, but a higher price.
「」を参照してください。 透析器の超濾過係数による分類
According to the ultrafiltration coefficient, there are two different Dialyzerのタイプ:
1. Low ultrafiltration coefficient Dialyzer. Ultrafiltration coefficient <15ml/(mmHg.h㎡), including copper imitation membrane, cuprammonium membrane, blood imitation membrane, and cellulose acetate membrane.
2. High-throughput and high-efficiency Dialyzer. Ultrafiltration coefficient> 15 ml/(mmHg.h㎡), has a very high removal rate for medium molecular weight substances and can remove large molecular weight β2-microglobulin and other macromolecular substances. Typical high-efficiency HemoDialyzers include polysulfone membrane series, PAN membrane, PMMA membrane, and cellulose acetate membrane Dialyzer.
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